Three cases are presented dealing with rare lethal complications durin
g the insertion of pulmonary artery catheters (PAC). Complications res
ulting from catheter insertion have been reported on numerous occasion
s; we report further examples of inadequate insertion techniques. Case
reports. Deviating from the recommended guidelines was presumably a s
ignificant factor in the development of fatal pulmonary bleeding. In t
he first case PAC-related perforation of the right ventricle resulting
in cardiac tamponade was found at autopsy. Clinically, this perforati
on had not been noticed. A guidewire was allegedly employed during ins
ertion. The diameter of the perforation (3 mm) suggests that either th
e balloon was deflated or the guidewire was used incautiously. In the
second case during insertion the balloon was described as being inflat
ed ''after'' reaching a wedge position. Considering this fact, cathete
r migration with perforation of a distal small artery was evident. Dis
tal migration is more frequently associated with rupture of the pulmon
ary artery. In the third case we found a sequence of intimal lesions i
n the right main pulmonary artery and a segmental artery of the right
lung. This high number of PAC-induced lesions is unusual and suggests
inappropriate inflation technique. Conclusions, Based on our observati
ons, we believe the low complication rate associated with PAC insertio
n has led to deviations from the normal guidelines by some physicians.
Despite adequate precautions and insertion technique, iatrogenic lesi
ons cannot be avoided in all cases because of pre-existing risk factor
s. For the evaluation of catheter-induced complications and the develo
pment of a risk profile, more autopsies as well as more detailed clini
cal documentation would be necessary.