T. Sato et al., CHANGES IN LIVER BLOOD-FLOW AFTER HEPATECTOMY IN CONSCIOUS DOGS, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 26(9), 1996, pp. 688-693
Hepatic circulation after hepatectomy was investigated in conscious do
gs under fasting and feeding conditions. After a 40% hepatectomy, both
the hepatic arterial and portal blood how were measured simultaneousl
y using ultrasonic transit time flowmeters. During fasting, the total
hepatic blood flow (i.e., the sum of arterial and portal blood flow) c
hanged in a biphasic pattern after hepatectomy. The first peak (517.9
+/- 42.7 ml/min; 130.1% of preoperative Bow) was seen on the 1st posto
perative day (POD) and the second peak (444.8 +/- 25.6 ml/min; 112.7%
of preoperative dow) occurred on the 7th POD, The portal how demonstra
ted the same biphasic changes as the total hepatic how, although the h
epatic arterial dow showed only the first peak. A heart rate analysis
suggested that the first peak was probably due to hyperdynamic circula
tory conditions, as has been previously reported. In addition, the exi
stence of the second peak was established by the present study. The po
stprandial hepatic blood dow decreased during the first 2 weeks postop
eratively, but exceeded the presurgical levels on PODs 21 and 28.