In clinical populations, it has been reported that African-American pa
tients are more likely to receive a diagnosis of schizophrenia than si
milar Caucasian patients. Factors contributing to this racial discrepa
ncy are poorly defined. The authors examined the hypothesis that racia
l differences in severity of first-rank symptoms of schizophrenia cont
ribute to this diagnostic difference. Patients were recruited as part
of the DSM-IV Field Trial for Schizophrenia and Other Psychotic Disord
ers, and evaluated using a structured rating instrument. Symptom and d
iagnostic comparisons were performed between black and white patients.
Black patients were significantly more likely than white patients to
be diagnosed with schizophrenia and less likely with psychotic depress
ion. Racial differences in symptom profiles were observed with black p
atients demonstrating more severe psychotic symptoms, in general, and
first-rank symptoms, specifically. There were no racial differences in
rates of affective syndromes or severity of affective symptoms. Racia
l disparity in diagnosis of psychotic patients may be in part secondar
y to more severe first-rank symptoms in black patients, causing clinic
ians to stray from DSM-III-R criteria.