LONG-RANGE REPRESSION IN THE DROSOPHILA EMBRYO

Authors
CAI HN ARNOSTI DN LEVINE M
Citation
Hn. Cai et al., LONG-RANGE REPRESSION IN THE DROSOPHILA EMBRYO, Proceedings of the National Academy of Sciences of the United Statesof America, 93(18), 1996, pp. 9309-9314
Citations number
29
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
93
Issue
18
Year of publication
1996
Pages
9309 - 9314
Database
ISI
SICI code
0027-8424(1996)93:18<9309:LRITDE>2.0.ZU;2-Z
Abstract
Transcriptional repressors can be characterized by their range of acti on on promoters and enhancers. Short-range repressors interact over di stances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressor s act over several kilobases to silence basal promoters. We describe r ecent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasti ng types of gene regulation that are made possible by short- and long- range repressors.