LYMPHOPROLIFERATIVE DISORDERS IN SOTOS SYNDROME - OBSERVATION OF 2 CASES

Sotos syndrome is included among the overgrowth disorders, most of whi ch have an increased risk of neoplasms. Sotos syndrome does not appear to be related to a specific tumor type, but rather to the development of solid tumors of ectodermal or mesodermal origin in general. We rep ort on two Sotos syndrome patients who developed a non-Hodgkin lymphom a and an acute lymphoblastic leukaemia, respectively. Our experience s uggests that there may exist a high frequency of lymphoproliferative d isorders in Sotos syndrome, and points out the importance of a long-te rm follow-up of Sotos syndrome patients, to detect a possible neoplast ic evolution. (C) 1996 Wiley-Liss, Inc.