ANTAGONISM OF TEICOPLANIN AND VANCOMYCIN ACTIVITY BY CHOCOLATIZED MUELLER-HINTON AGAR

Chocolatized (80 degrees C, 13 min) Mueller-Hinton agar antagonized th e inhibitory activities of teicoplanin and vancomycin against referenc e strains of Streptococcus pyogenes, Streptococcus agalactiae, Strepto coccus pneumoniae, Staphylococcus aureus, and Enterococcus faecalis. T his antagonism was due to heat-exposed sheep erythrocytes, sheep hemog lobin, and the supernatant fluid from lysed sheep erythrocytes, but no t to sheep serum. Neither water-soluble cholesterol, bovine albumin, b ovine serum, hematin, hemin nor egg yolk suspension antagonized teicop lanin and vancomycin.