Within 1987-1995 the authors observed 16 cases of tuberculosis in HIV-
infected patients which accounted for 26.7% of AIDS patients treated b
y them. 14 cases were diagnosed intravitally, 2 postmortem. Infiltrati
ve, generalized, cavernous, intrathoracic lymph node, intraabdominal l
ymph node tuberculosis and tuberculous pleurisy were identified in 5,
6, 2, 1, 1 and 1 patients, respectively. 6 patients from the above are
still alive and are receiving treatment (5 of them with infiltrative
tuberculosis), 10 died. Tuberculosis course and outcomes in HIV-infect
ed subjects depended on the stage of their immunodeficiency. In modera
te immunodeficiency (CD4-lymphocyte > 200/mm(3)) tuberculosis ran, as
a rule, as local and infiltrative, sensitive to specific therapy. In s
evere damage to immune system (CD4 < 100/mm(3)) tuberculosis acquired
a generalized course, sometimes fulminant, resistant to treatment. It
is inferred that HIV-infected subjects with immunodeficiency need tube
rculosis prophylaxis with isoniazide or rifampicin.