HORMONE-SENSITIVITY IN GLOMERULONEPHRITIS PATIENTS

Hormone-sensitivity in patients suffering from glomerulonephritis of n ephrotic type was assessed cytochemically by corticosteroid action on activity of mitochondrial enzymes (alpha-glycerophosphate dehydrogenas e, succinate dehydrogenase) and by sensitivity of peripheral blood mon onuclear cells to antiproliferative effect of dexamethasone in vitro. in glucocorticosteroid-sensitive patients the activity of alpha-glycer ophosphate dehydrogenase, succinate dehydrogenase rises in interaction with prednisolone in vitro. In the resistant patients enzymatic activ ity in lymphocytes came down, peripheral blood mononuclear cells befor e and in the course of treatment retained resistance to glucocorticoid s irrespective of the treatment results. Alpha-glycerophosphate dehydr ogenase to; succinate dehydrogenase index varied from 0 to 0.33 and 0. 4 to 5.1 in the resistant and sensitive patients, respectively.