RELATIONSHIP BETWEEN BIRTH-WEIGHT AND AWAKE BLOOD-PRESSURE IN CHILDREN AND ADOLESCENTS IN ABSENCE OF INTRAUTERINE GROWTH-RETARDATION

This study was designed to examine the relationship between birth weig ht (BW) and ambulatory blood pressure in children and adolescents, bor n at term in absence of intrauterine growth retardation. Twenty-four h our ambulatory blood pressure monitoring (ABPM) was performed on 332 c hildren (150 boys), aged from 6 to 16 years. Subjects were stratified by BW tertiles and age. ABPM was performed using SpaceLabs 90207 monit or during a regular school day. Blood pressure (BP) was measured every 20 min from 06:00 to 24:00, and thereafter every 30 min. Means of sys tolic BP (SEP) and diastolic BP (DBP) during 24 h, daytime (08:00 to 2 2:00), and nighttime (24:00 to 06:00) were calculated. Systolic and di astolic load was estimated as the percentage of measurements above the age- and sex-specific 95th percentile during the 24 h. BW was inverse ly related to daytime SEP (P = .04) and SEP load (P = .04) when contro lled for sex, current height, ponderal index (weight/height(3)), and a ge. The predictive values of daytime SBP throughout the pediatric age group in the two extreme tertiles of BW (lowest, 2,500 to 3.200 kg; an d highest, 3.501 to 4.820 kg) were obtained from regression equations including SEP during activity period or SEP load and age. Children who had lower BW tended to have higher daytime SEP or SEP load at any age although this difference was not statistically significant. These dif ferences became more evident as the subjects got older. BW is a determ inant of daytime SEP even in the absence of intrauterine growth retard ation. The influence of BW seems to increase with age.