CLINICAL AND HISTOLOGIC ASPECTS OF BIPHASIC CALCIUM-PHOSPHATE CERAMIC(BCP) USED IN CONNECTION WITH IMPLANT PLACEMENT

A granulate of biphasic calcium phosphate ceramic (BCP), composed of 5 0% hydroxyapatite and 50% beta-tricalcium phosphate, was used, in man, to fill defects resulting from cyst enucleation. The defects were cov ered with e-PTFE membranes, and at the re-entry procedure after six mo nths, it was possible to see that the defects were filled by a newly f ormed tissue with the macroscopic features of mature bone. Smooth tita nium implants were inserted in the newly regenerated tissue. Histologi cal examination of this tissue showed that most of the particles were lined by newly formed bone. Some particles were undergoing resorption processes and were being gradually substituted by newly formed bone. N o inflammatory infiltrate was present. Our results point, in conclusio n, to a good biocompatibility and osteoconductivity of this material. (C) 1996 Elsevier Science Limited.