THE EFFECT OF ONDANSETRON ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF TEMAZEPAM

The objective of this study was to determine the effects of ondansetro n on the pharmacokinetics of temazepam and on pharmacodynamics relevan t to its use as oral premedication. Twenty-four healthy volunteers (12 of each sex) were administered the following oral treatments in a ran domised, double-blind crossover design: temazepam 20 mg plus placebo; or temazepam 20 mg plus ondansetron 8 mg. Blood samples were taken for plasma temazepam assay at intervals up to 32 h after administration. In addition, a brief battery of psychomotor tests was administered 1 h prior to dosing and I and 4 h after dosing. Analysis of the derived p harmacokinetic parameters showed no differences between the treatments described above. Analysis of data fi om the dynamic measures likewise showed no difference between the treatments. It was concluded that th e co-administration of ondansetron did not influence the pharmacokinet ics or pharmacodynamic actions of temazepam.