The objective of this study was to determine the effects of ondansetro
n on the pharmacokinetics of temazepam and on pharmacodynamics relevan
t to its use as oral premedication. Twenty-four healthy volunteers (12
of each sex) were administered the following oral treatments in a ran
domised, double-blind crossover design: temazepam 20 mg plus placebo;
or temazepam 20 mg plus ondansetron 8 mg. Blood samples were taken for
plasma temazepam assay at intervals up to 32 h after administration.
In addition, a brief battery of psychomotor tests was administered 1 h
prior to dosing and I and 4 h after dosing. Analysis of the derived p
harmacokinetic parameters showed no differences between the treatments
described above. Analysis of data fi om the dynamic measures likewise
showed no difference between the treatments. It was concluded that th
e co-administration of ondansetron did not influence the pharmacokinet
ics or pharmacodynamic actions of temazepam.