COMPARISON OF LIQUID-CHROMATOGRAPHY, CAPILLARY ELECTROPHORESIS AND SUPERCRITICAL-FLUID CHROMATOGRAPHY IN THE DETERMINATION OF LOSARTAN POTASSIUM DRUG SUBSTANCE IN COZAAR(R) TABLETS

Authors
WILLIAMS RC ALASANDRO MS FASONE VL BOUCHER RJ EDWARDS JF
Citation
Rc. Williams et al., COMPARISON OF LIQUID-CHROMATOGRAPHY, CAPILLARY ELECTROPHORESIS AND SUPERCRITICAL-FLUID CHROMATOGRAPHY IN THE DETERMINATION OF LOSARTAN POTASSIUM DRUG SUBSTANCE IN COZAAR(R) TABLETS, Journal of pharmaceutical and biomedical analysis, 14(11), 1996, pp. 1539-1546
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
14
Issue
11
Year of publication
1996
Pages
1539 - 1546
Database
ISI
SICI code
0731-7085(1996)14:11<1539:COLCEA>2.0.ZU;2-5
Abstract
Reversed phase liquid chromatography, micellar electrokinetic chromato graphy, and packed column supercritical fluid chromatography were used to measure the amount of Losartan Potassium drug substance in pharmac eutical tablets. Tablet extract samples were analyzed and results were used to compare accuracy, precision, and linearity of calibration of the instrumental techniques. All three techniques have satisfactory pr ecision (less than 1% RSD) and accuracy to be used for the analysis of the drug substance in tablets and the advantages of each technique ar e discussed.