T. Sugahara et al., ENHANCEMENT OF IGM PRODUCTION BY HUMAN PERIPHERAL-BLOOD LYMPHOCYTES BY RICE FERMENTED SEASONING UNDER SERUM-FREE CULTIVATION, Journal of fermentation and bioengineering, 82(1), 1996, pp. 77-79
Rice fermented seasoning (RFS) enhanced IgM production by human periph
eral blood lymphocytes (PBL) in vitro. The IgM production by the PBL c
ultured in serum-free medium supplemented with 3% RFS was enhanced abo
ut 3-fold. However, rice fermented extracts did not enhance IgG produc
tion by human PBL cultured under similar conditions. RFS showed no mit
ogenic activity toward the PBL in this study. These results indicate t
hat RFS stimulates immunoglobulin productivity of each IgM-producing P
BL.