FIBROBLASTS FROM LI-FRAUMENI PATIENTS ARE RESISTANT TO LOW DOSE-RATE IRRADIATION

Authors
SPROSTON ARM BOYLE JM HEIGHWAY J BIRCH JM SCOTT D
Citation
Arm. Sproston et al., FIBROBLASTS FROM LI-FRAUMENI PATIENTS ARE RESISTANT TO LOW DOSE-RATE IRRADIATION, International journal of radiation biology, 70(2), 1996, pp. 145-150
Citations number
37
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Nuclear Sciences & Tecnology
Journal title
International journal of radiation biology → ACNP
ISSN journal
09553002
Volume
70
Issue
2
Year of publication
1996
Pages
145 - 150
Database
ISI
SICI code
0955-3002(1996)70:2<145:FFLPAR>2.0.ZU;2-Y
Abstract
A group of adult skin fibroblast cultures from four individuals repres enting Li-Fraumeni families with different mutations in the p53 gene w ere found to be resistant to low dose-rate (0.011 Gy per min) Co-60 ra diation when compared with a control group of four cultures from norma l individuals. The Li-Fraumeni fibroblasts, which could not be disting uished from controls after high dose rate (1.07 Gy per min) irradiatio n, were shown to be heterozygous (+/mut) at the p53 locus at the time of irradiation.