LACTARANE TYPE SESQUITERPENOIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS AND OTHER, NEW METABOLITES FROM SUBMERGED CULTURES OF LENTINELLUS-COCHLEATUS (PERS EX FR) KARST

Authors
WUNDER A ANKE T KLOSTERMEYER D STEGLICH W
Citation
A. Wunder et al., LACTARANE TYPE SESQUITERPENOIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS AND OTHER, NEW METABOLITES FROM SUBMERGED CULTURES OF LENTINELLUS-COCHLEATUS (PERS EX FR) KARST, Zeitschrift fur Naturforschung. C, A journal of biosciences, 51(7-8), 1996, pp. 493-499
Citations number
19
Categorie Soggetti
Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
51
Issue
7-8
Year of publication
1996
Pages
493 - 499
Database
ISI
SICI code
0939-5075(1996)51:7-8<493:LTSAIO>2.0.ZU;2-1
Abstract
Three known sesquiterpenoids of the lactarane and secolactarane type, deoxylactarorufin A (1), blennin A (2) and blennin C (3), have been ob tained from cultures of Lentinellus cochleatus (Basidiomycetes) togeth er with the new metabolites (Z)-2-chloro-3-(4-methoxyphenyl)-2-propen- 1-ol (4) and lentinellone (5), a protoilludane derivative. The structu res were determined by spectroscopic Investigations. 1, 2 and 3 are po tent inhibitors of leukotriene biosynthesis in rat basophilic leukemia (RBL-1) cells and human peripheral blood leukocytes (PBL).