FULMINANT LIVER-FAILURE WITH NECROTIZING FOCI IN THE LIVER, SPLEEN AND LYMPH-NODES IN CELIAC-DISEASE DUE TO MALIGNANT-LYMPHOMA

A 65-year-old female with celiac disease developed cholestatic jaundic e and fatal liver failure. Investigations revealed widespread necrotic foci in the liver, spleen and mesenteric lymph nodes, changes reminis cent of the mesenteric lymph node cavitation syndrome, which is known to complicate celiac disease. In addition, malignant lymphoid cells we re present infiltrating hepatic sinusoids, lymph nodes and spleen. The se features are typical of hepatosplenic lymphoma, a rare type of peri pheral T cell lymphoma with T cell receptor rearrangement. Lymphorecti cular malignancy complicating celiac disease may present with fulminan t liver disease.