NEW APPROACHES TO MANAGEMENT OF MULTIPLE-MYELOMA

A new era of multiple myeloma (MM) management includes new approaches such as genetic marking and gene therapy, immunotherapy, stimulation o f graft versus myeloma effect, etc. Intensive clinical research is als o focused on the detection of minimal residual disease and bone marrow purging. Autoregulatory loop of myeloma cells and detection of genes responsible for pathological transformation of B-line cells is of grea t research interest. Clinical trials have begun and the first results are promising, though preliminary. The safety of the patients and the public must be a major concern of all investigators. The combinations of new types of therapeutical approaches with the most efficient regim ens used until now could form a new type of MM management strategy tha t better involves minimal residual disease.