THE NEUROIMMUNOLOGY OF MULTIPLE-SCLEROSIS

The aim of this clinical review is to highlight recent advances in imm unology, as well as new information from selected other areas, which h ave led to a better appreciation of the neuroimmunologic mechanisms in volved in Multiple sclerosis (MS). New data on immunopathology, the cy tokine network, and the role of oligodendrocytes, lymphocytes, and end othelial cells in this disease, have produced novel therapeutic approa ches. New information on clinical course and neuroimaging disease feat ures, as well as the role of genetic factors and infectious agents, ha ve also improved our understanding of the immune basis for MS.