A HIGH-FREQUENCY OF INDUCTION OF CHROMOSOME-ABERRATIONS IN THE FIBROBLASTS OF LEC STRAIN RATS BY X-IRRADIATION

The LEC strain of rats (LEG rats), originally developed as a model for hereditary fulminant hepatitis, is highly sensitive to whole-body X-i rradiation when compared to WKAH strain of rats (WKAH rats). The prese nt results showed that frequencies of certain types of chromosome aber rations induced by in vitro X-irradiation in the fibroblasts of LEC ra ts were higher than those of WKAH rats. In particular, frequencies of chromatid gaps and chromosome exchanges in LEC cells were higher appro ximately 4- to 5-fold and 6- to 8-fold, respectively, than those of WK AH cells.