PEMPHIGUS FOLIACEUS WITH TYPICAL HISTOLOGICAL AND IMMUNOHISTOLOGICAL FINDINGS IN A DOG

A seven-year-old female mongrel dog showed incurable skin lesions for about a year. The lesions were at nasal bridge and periocular area, an d were composed of crust formation and scaling. Biopsy specimens from the skin lesions possessed with multiple intraepidermal pustules conta ining many acantholytic keratinocytes. Direct immunoperoxidase stain u sing paraffin-embedded section showed IgG deposition at the intercellu lar area of upper epidermis and follicular infundibula. IgG was not de tected at basement membrane zone. Clinical and pathological findings o f the present case were identical to those of pemphigus foliaceus, an uncommon pustular autoimmune skin disease.