There are approximately 14 million persons with diabetes in the United
States. These patients must cope with the serious complications of th
is disease, including neuropathy and impaired circulation (leading to
the ''diabetic foot'' and possible amputation), renal disease, cardiov
ascular disease, and retinopathy (possibly leading to blindness). Alth
ough onychomycosis is no more common in diabetics than in the general
population, it poses a greater risk because of the possible sequelae.
Most notably, impaired sensation can make many diabetics less aware of
minor abrasions and ulcerations on their feet that may be caused by t
rauma from poor nail grooming or by the nail changes characteristic of
onychomycosis. These lesions, in turn, may develop into serious bacte
rial infections and contribute to the severity of the diabetic foot. T
hus there is an important clinical rationale for treating diabetic pat
ients with fungal nail infections. A secondary benefit is the improved
self-esteem and enhanced quality of life.