ACUTE FULMINATING BABESIOSIS IN HAMSTERS INFECTED WITH BABESIA-MICROTI

In this study, Babesia microti (ATCC30222) from mice was adapted to go lden hamsters. The parasite was passaged to immunosuppressed and then adapted to normal hamsters. When 30 normal hamsters were inoculated wi th this strain, parasitaemia increased to 74% of erythrocytes by day 7 and 70% of the hamsters died. By day 12, parasitaemia extended to 90% , with 97% mortality. Hearts and kidneys from infected animals were en larged. Histopathology revealed acute myocarditis, hepatitis, pneumoni tis, glomerulonephritis and splenomegaly. Giemsa, Acridine Orange and Rhodamine staining of the parasite were compared. Scanning electron mi croscopy of blood from infected hamsters revealed from 1 to 5 intra-er ythrocytic parasites. Copyright (C) 1996 Australian Society for Parasi tology.