PREVENTION OF CISPLATINUM NEPHROTOXICITY IN A HIGH-RISK PATIENT

A 64-year-old woman, affected by stage me epithelial ovarian cancer, e xperienced acute renal failure after the first cycle of chemotherapy w ith cyclophosphamide and cis-platinum, despite standard prophylactic m easures of hydration-diuresis, In this paper we report data obtained d uring 5 additional cycles of chemotherapy. The schedule of treatment w as modified by dividing standard dose of cis-platinum by three and adm inistering this divided dose for 3 days. The following five cycles of treatment did not cause a clinically relevant impairment of glomerular function or evident tubular toxicity. A high-risk patient was treated safely combining hydration-diuresis measures with lengthening of cis- platinum administration over 3 days.