IN-VITRO ACTIVITIES OF TROVAFLOXACIN AGAINST 557 STRAINS OF ANAEROBIC-BACTERIA

The antimicrobial activity of trovafloxacin for 557 strains of anaerob ic bacteria was determined by the National Committee for Clinical Labo ratory Standards-approved Wadsworth agar dilution technique. The speci es tested included Bacteroides fragilis (n = 91), other members of the B. fragilis group (n = 130), Campylobacter gracilis (n = 15), other B acteroides spp. (n = 16), Prevotella spp. (n = 49), Porphyromonas spp. (n = 15), Fusobacterium spp. (n = 62), Bilophila wadsworthia (n = 24) , Sutterella wadsworthensis (n = 21), Clostridium spp. (n = 61), Pepto streptococcus spp. (n = 38), and gram-positive non-spore-forming rods (n = 35). Trovafloxacin inhibited all strains of B. fragilis at less t han or equal to 0.5 mu g/ml, 99% of other B. fragilis group species at less than or equal to 2 mu g/ml, and 96% of all anaerobes tested at l ess than or equal to 2 mu g/ml.