Prescription drug abuse can involve medications not usually considered
to have addictive potential. Clonidine is a rare, but important, atyp
ical drug of abuse. Atypical prescription abuse was discovered in a pa
tient who had a history of alcohol and drug abuse. Clonidine produced
a state that the patient identified as similar to the condition result
ing from the use of opioids. This article offers a framework for ident
ifying atypical prescription drug abuse and suggests guidelines for pr
evention and management.