SIMPLE METHOD FOR DETECTION OF MYH11 DNA REARRANGEMENTS IN PATIENTS WITH INV(16)(P13Q22) AND ACUTE MYELOID-LEUKEMIA

Authors
VANDERREIJDEN BA MARTINET D DAUWERSE JG GILES RH WESSELS JW BEVERSTOCK GC SMIT B MUHLEMATTER D BELLOMO MJ GABERT J LAFAGEPOCHITALOFF M REIFFERS J BILHOUNABERA C VANOMMEN GJB HAGEMEIJER A BREUNING MH
Citation
Ba. Vanderreijden et al., SIMPLE METHOD FOR DETECTION OF MYH11 DNA REARRANGEMENTS IN PATIENTS WITH INV(16)(P13Q22) AND ACUTE MYELOID-LEUKEMIA, Leukemia, 10(9), 1996, pp. 1459-1462
Citations number
19
Categorie Soggetti
Hematology,Oncology
Journal title
Leukemia → ACNP
ISSN journal
08876924
Volume
10
Issue
9
Year of publication
1996
Pages
1459 - 1462
Database
ISI
SICI code
0887-6924(1996)10:9<1459:SMFDOM>2.0.ZU;2-5
Abstract
The pericentric inversion on chromosome 16 [inv(16)(p13q22)] and relat ed t(16;16)(p13;q22) are recurrent aberrations associated with acute m yeloid leukemia (AML) M4 Eo. Both abberations result in a fusion of th e core binding factor beta (CBFB) and smooth muscle myosin heavy chain gene (MYH11). A selected genomic 6.9-kb BamH1 probe detects MYH11 DNA rearrangements in 18 of 19 inv(16)/t(16;16) patients tested using Hin dIII digested DNA. The rearranged fragments were not detectable after remission in two cases tested, while they were present after relapse i n one of these two cases tested.