SYNTHESIS OF IMIDAZO[1',2'-3,4]PYRIMIDO[6 ,1-ALPHA]ISOQUINOLINE AND PYRIMIDO[1',2'-3,4]PYRIMIDO[6,1-ALPHA]ISOQUINOLINE RING-SYSTEMS BY TANDEM CYCLIZATION

Authors
FULOP F WAMHOFF H SOHAR P
Citation
F. Fulop et al., SYNTHESIS OF IMIDAZO[1',2'-3,4]PYRIMIDO[6 ,1-ALPHA]ISOQUINOLINE AND PYRIMIDO[1',2'-3,4]PYRIMIDO[6,1-ALPHA]ISOQUINOLINE RING-SYSTEMS BY TANDEM CYCLIZATION, Magyar kemiai folyoirat, 102(11), 1996, pp. 477-483
Citations number
31
Categorie Soggetti
Chemistry
Journal title
Magyar kemiai folyoirat → ACNP
ISSN journal
00250155
Volume
102
Issue
11
Year of publication
1996
Pages
477 - 483
Database
ISI
SICI code
0025-0155(1996)102:11<477:SOI,AP>2.0.ZU;2-I
Abstract
The reactions of koxy-1,2,3,4-tetrahydroisoquinoline-1-acetonitrile 3 and 4 with 2-chloroethyl and 3-chloropropyl isocyanates resulted in ur ethanes 5-8, which were transformed with sodium methylate into the new ring systems 9.10-dimethoxy- and 9,10-diethoxy-5H-2,3,7,8,12b, -hexah ydroimidazo[1',2':3,4]pyrimido[6,1-a]isoquin olin-5-one (9, 10) and 11 ,12-dimethoxy- and 11,12-diethoxy-2H, 6H-3,4,8,9,13b,14-hexahydropyrim ido [1',2':3,4]pyrimido[6,1-a]isoquinolin-6-one (11, 12), by tandem cy clization.