INHIBITION OF MEVALONATE 5-PYROPHOSPHATE DECARBOXYLASE BY A PROLINE-CONTAINING TRANSITION-STATE ANALOG

Authors
VLATTAS I DELLUREFICIO J KU E BOHACEK R ZHANG XL
Citation
I. Vlattas et al., INHIBITION OF MEVALONATE 5-PYROPHOSPHATE DECARBOXYLASE BY A PROLINE-CONTAINING TRANSITION-STATE ANALOG, Bioorganic & medicinal chemistry letters, 6(17), 1996, pp. 2091-2096
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
17
Year of publication
1996
Pages
2091 - 2096
Database
ISI
SICI code
0960-894X(1996)6:17<2091:IOM5DB>2.0.ZU;2-R
Abstract
Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from m evalonate. Based on a hypothetical model of the transition state of th is enzymatic transformation we have synthesized novel hydroxyacetyl pr oline analogs that are potent inhibitors of the enzyme. Copyright (C) 1996 Elsevier Science Ltd