SYNTHESIS OF CYCLIC-PEPTIDES MODELED ON THE MICROCYSTIN AND NODULARINRINGS

Authors
TAYLOR C QUINN RJ ALEWOOD P
Citation
C. Taylor et al., SYNTHESIS OF CYCLIC-PEPTIDES MODELED ON THE MICROCYSTIN AND NODULARINRINGS, Bioorganic & medicinal chemistry letters, 6(17), 1996, pp. 2107-2112
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
17
Year of publication
1996
Pages
2107 - 2112
Database
ISI
SICI code
0960-894X(1996)6:17<2107:SOCMOT>2.0.ZU;2-5
Abstract
Several precursor cyclic peptides modelled on the ring systems of micr ocystin-LR and nodularin were synthesized. Synthesis was best achieved using solid-phase cyclization with solution-phase methods being succe ssful in only one instance. These precursor cyclic peptides are suitab le for elaboration with Adda-like hydrophobic side chains in order to produce structure-activity information. Copyright (C) 1996 Elsevier Sc ience Ltd