NON THIAZOLIDINEDIONE ANTIHYPERGLYCEMIC AGENTS .1. ALPHA-HETEROATOM SUBSTITUTED BETA-PHENYLPROPANOIC ACIDS

Authors
BUCKLE DR CANTELLO BCC CAWTHORNE MA COYLE PJ DEAN DK FALLER A HAIGH D HINDLEY RM JEFCOTT LJ LISTER CA PINTO IL RAMI HK SMITH DG SMITH SA
Citation
Dr. Buckle et al., NON THIAZOLIDINEDIONE ANTIHYPERGLYCEMIC AGENTS .1. ALPHA-HETEROATOM SUBSTITUTED BETA-PHENYLPROPANOIC ACIDS, Bioorganic & medicinal chemistry letters, 6(17), 1996, pp. 2121-2126
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
17
Year of publication
1996
Pages
2121 - 2126
Database
ISI
SICI code
0960-894X(1996)6:17<2121:NTAA.A>2.0.ZU;2-4
Abstract
The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antid iabetic agents can be replaced by a range of alpha-heteroatom function alised beta-phenylpropanoic acids. alpha-Oxy-carboxylic acids show pot ent antidiabetic activity and one compound, the alpha-ethoxyacid 15 (S E 213068), is one of the mast potent antihyperglycaemic agents yet rep orted. Copyright (C) 1996 Elsevier Science Ltd