NON THIAZOLIDINEDIONE ANTIHYPERGLYCEMIC AGENTS .2. ALPHA-CARBON SUBSTITUTED BETA-PHENYLPROPANOIC ACIDS

Authors
BUCKLE DR CANTELLO BCC CAWTHORNE MA COYLE PJ DEAN DK FALLER A HAIGH D HINDLEY RM JEFCOTT LJ LISTER CA PINTO IL RAMI HK SMITH DG SMITH SA
Citation
Dr. Buckle et al., NON THIAZOLIDINEDIONE ANTIHYPERGLYCEMIC AGENTS .2. ALPHA-CARBON SUBSTITUTED BETA-PHENYLPROPANOIC ACIDS, Bioorganic & medicinal chemistry letters, 6(17), 1996, pp. 2127-2130
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
17
Year of publication
1996
Pages
2127 - 2130
Database
ISI
SICI code
0960-894X(1996)6:17<2127:NTAA.A>2.0.ZU;2-Z
Abstract
The thiazolidine-2,4-dione ring of insulin sensitising antidiabetic ag ents can be replaced by alpha-acyl-, alpha-alkyl- and alpha-(aralkyl)- carboxylic acids. Inclusion of an additional lipophilic moiety affords compounds 14 and 16, equipotent to BRL 48482. Copyright (C) 1996 Else vier Science Ltd