Background: Lesions of the calvaria (cranial vault), whether benign or
malignant, are rare, and the number that require surgical attention i
s very limited. During a 13-year period, 42 patients ranging in age fr
om 13 to 82 years were treated surgically at our institution for lesio
ns involving primarily the calvaria. The patients were found to have 1
6 benign lesions, 21 malignant lesions, and 5 pathologically ill-defin
ed lesions. At last follow-up, 23 patients were still alive. Methods:
Criteria for choosing surgery as the preferred therapeutic modality in
cluded (a) uncertain diagnosis; (b) benign lesions with a high probabi
lity of total removal; 3) malignant lesions that represented the only
residue of a systemic malignancy that was in remission; or (d) lesions
that were rapidly enlarging, were causing significant symptoms, or we
re unresponsive to radiation or chemotherapy. Results: Preoperative ne
edle biopsy was useful for some patients in establishing a definitive
diagnosis and in providing the basis for the most effective treatment
strategy. Most lesions were treated with either craniectomy alone (n =
16) or with craniectomy and cranioplasty (n = 26). Six of the 42 pati
ents had postoperative complications. There was no operative mortality
. Conclusion: This review of a series of patients with calvarial lesio
ns provides an outline of the overall diagnostic workup and management
of this unique patient population.