Oxygen saturation monitoring (pulse oximetry) has markedly improved me
dical care in many fields, including anesthesiology, critical care, an
d newborn intensive care. In obstetrics, fetal heart rate monitoring r
emains the standard for intrapartum assessment of fetal well-being. Fe
tal heart rate monitoring is sensitive but nonspecific for detecting f
etal compromise. Additional clinical information is needed to discern
those fetuses not at risk for development of intrapartum acidosis to a
void unnecessary intervention. Fetal oxygen saturation monitoring is a
new technique currently under development. This article reviews the e
volution of intrapartum fetal oxygen saturation monitoring and propose
s directions for future investigation.