Cjm. Degroot et al., BIOCHEMICAL-EVIDENCE OF IMPAIRED TROPHOBLASTIC INVASION OF DECIDUAL STROMA IN WOMEN DESTINED TO HAVE PREECLAMPSIA, American journal of obstetrics and gynecology, 175(1), 1996, pp. 24-29
OBJECTIVE: Reduced trophoblastic migration into the decidua during the
first half of pregnancy is a fundamental abnormality in preeclampsia.
CA 125 and insulin-like growth factor binding protein-1 are major end
ometrial proteins whose primary sources are decidual epithelial and st
romal cells, respectively. We hypothesized that reduced trophoblastic
invasion in pregnancies destined for preeclampsia would affect the mat
ernal vascular deportation of these decidual proteins. STUDY DESIGN: C
A 125 and insulin-like growth factor binding protein-1 concentrations
were analyzed by radioimmunoassays of plasma from preeclamptic and mat
ched control patients in a longitudinal, nested case-control study. RE
SULTS: CA 125 concentrations did not differ with respect to pregnancy
outcome or trimester. Midtrimester plasma insulin-like growth factor b
inding protein-1 concentrations were significantly lower in women who
later had preeclampsia compared with normal pregnant controls. CONCLUS
ION: These findings provide biochemical evidence that abnormalities of
trophoblastic invasion affect the maternal vascular deportation of a
decidual stromal protein. Lower circulating concentrations of insulin-
like growth factor binding protein-1 in women destined to have preecla
mpsia were observed 12 to 26 weeks before the onset of clinical signs
of this syndrome.