VULVAR ANGIOMYOFIBROBLASTOMA - CLINICOPATHOLOGICAL ANALYSIS OF 6 CASES

Clinicopathologic, immunohistochemical, ultrastructural, and flow cyto metric analyses were performed on vulvar angiomyofibroblastomas in six women (ages 32 to 46 years; average age, 41.3 years). The tumors were all well circumscribed, and measured 2 to 9 cm in greatest dimension. Five tumors were clinically diagnosed as Bartholin's gland cysts. At histologic analysis, the tumors were characterized by alternating hype rcellular and hypocellular edematous areas with abundant blood vessels . The hypercellular areas showed a perivascular proliferation of spind le-shaped and round cells, which often formed small nests or epithelio id arrangements, and a short fascicular pattern of spindle cells. The proliferating vessels were thin-walled and capillary-sized. Cellular a typia and mitotic figures were absent. Two tumors contained an adipose element, and one showed a prominent vascular proliferation reminiscen t of a capillary hemangioma. At immunohistochemical analysis, the tumo r cells were strongly positive for vimentin and desmin. Some cells wer e weakly positive for HHF35 and alpha-smooth muscle actin. Ultrastruct urally, one neoplasm showed fibroblastic differentiation. Flow cytomet ry revealed three tumors were DNA diploid and two were aneuploid. All tumors were excised, and none have recurred (average follow-up, 28.3 m onths). These results indicate that angiomyofibroblastomas contain het erogeneous components.