EVIDENCE OF BLOOD-BRAIN-BARRIER PERMEABILITY LEAKAGE FOR CIRCULATING HUMAN ALZHEIMERS BETA-AMYLOID-(1-42)-PEPTIDE/

Citation
R. Pluta et al., EVIDENCE OF BLOOD-BRAIN-BARRIER PERMEABILITY LEAKAGE FOR CIRCULATING HUMAN ALZHEIMERS BETA-AMYLOID-(1-42)-PEPTIDE/, NeuroReport, 7(7), 1996, pp. 1261-1265
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
09594965
Volume
7
Issue
7
Year of publication
1996
Pages
1261 - 1265
Database
ISI
SICI code
0959-4965(1996)7:7<1261:EOBPLF>2.0.ZU;2-6
Abstract
BRAINS from patients with Alzheimer's disease contain amyloid plaques which are composed of beta-amyloid peptide and are considered to play a causal role in the neuropathology of this disease. The origin of bet a-amyloid peptide in brain parenchyma and vessels of Alzheimer's disea se patients is not known. This study examined the permeability of the blood-brain barrier to beta-amyloid peptide in rats subjected to singl e or repeated episodes of global cerebral ischaemia followed by i.v. i njections of human synthetic beta-amyloid-(1-42)-peptide. Rats receivi ng beta-amyloid peptide after ischaemia demonstrated multifocal and wi despread accumulation of beta-amyloid peptide in hippocampus, cerebral cortex and occasionally in white matter. beta-Amyloid peptide penetra tion involved arterioles, veins and venules. Neuronal, glial and peric yte bodies were observed filled with beta-amyloid peptide. Direct evid ence that soluble human beta-amyloid-(1-42)-peptide crosses the blood- brain barrier and enters the brain from the circulation is thus provid ed for the first time.