LIPOID PROTEINOSIS - LIPID INCLUSIONS IN FIBROBLASTS

Lipoid proteinosis (LP) is a recessively, inherited disorder, characte rized by the deposition of hyaline-material in the oral cavity, skin a nd other tissues. We report a case of a 26-year-old woman with the cli nical features of LP. Oil-red staining fibroblasts cultured from a nod ular lesion, showed the presence of neutral fat distributed as drops, larger and much more numerous than in control cells. We demonstrate th at the cytoplasmic lipid inclusions present in vivo are observed in vi tro with routine lipid stains.