MOUSE THYROGLOBULIN - CONSERVATION OF SEQUENCE HOMOLOGY IN C-TERMINALIMMUNOGENIC REGIONS OF THYROGLOBULIN

cDNA encoding 287 amino acids of the C-terminus of mouse thyroglobulin was cloned and sequenced. The amino acid homology between mouse and r at thyroglobulin was 96%, and was 78% between mouse and human. It was found that mouse thyroglobulin completely shared homology with two thy roiditogenic peptides described by other investigators. These findings are consistent with our hypothesis that in murine experimental thyroi ditis, the primary thyroiditogenic epitopes are encoded by mouse-speci fic regions of thyroglobulin.