BIOTRANSFORMATION IN EGYPTIAN SPINY MOUSE ACOMYS-CAHIRINUS

The activities of several representative biotransformation enzymes wer e determined in male and female spiny mouse tissues, Cytochrome P450 m onooxygenase activity toward benzo(a)pyrene was significantly greater in female spiny mouse intestine than in males, Activity toward benzphe tamine in both sexes was high in the liver, with little activity in th e kidney and intestine. Sulfotransferase activity was high in kidney a nd intestine of female spiny mice but undetectable in the same tissues in males, Hepatic glutathione S-transferase activity towards 1-chloro -2,4-dinitrobenzene in females was significantly higher than in males, UDP-Glucuronosyltransferase activity toward 1-naphthol in both sexes in the kidney was significantly higher than hepatic and intestinal act ivity, Intestinal N-acetyltransferase activity towards 2-aminofluorene and beta-naphthylamine was significantly greater in females than male s, No consistent relation appeared to exist between biotransformation activities in spiny mouse and those in other related rodent species.