Ma. Vasilchenko et al., TOPOCHEMISTRY OF THE INITIAL-STAGES OF THE DISSOLUTION OF SINGLE-CRYSTALS OF ACETAMINOPHEN, Journal of pharmaceutical sciences, 85(9), 1996, pp. 929-934
Topochemistry of the initial stages of dissolution of monoclinic singl
e crystals of acetaminophen was studied. Etching pits were identified
with the sites of emerging dislocations. Etching of different faces wi
th a solution of ethyl acetate in carbon tetrachloride gave different
shapes of etching pits. An interpretation of this result was suggested
, based on the analysis of the anisotropy of the crystal structure. Et
ching of the same crystal face with different etching agents was shown
to result in different shapes of etching pits.