DECREASED L-ARGININE-NITRIC OXIDE PATHWAY IN CULTURED MYOBLASTS FROM SPONTANEOUSLY HYPERTENSIVE VERSUS NORMOTENSIVE WISTAR-KYOTO RATS

Authors
DUBOIS G
Citation
G. Dubois, DECREASED L-ARGININE-NITRIC OXIDE PATHWAY IN CULTURED MYOBLASTS FROM SPONTANEOUSLY HYPERTENSIVE VERSUS NORMOTENSIVE WISTAR-KYOTO RATS, FEBS letters, 392(3), 1996, pp. 242-244
Citations number
18
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
392
Issue
3
Year of publication
1996
Pages
242 - 244
Database
ISI
SICI code
0014-5793(1996)392:3<242:DLOPIC>2.0.ZU;2-O
Abstract
The hypertrophy of the arterial media exhibited by spontaneously hyper tensive rats is related to the hyperproliferation of their smooth musc le cells in culture, Using two methods to assay nitric oxide synthase activity, we showed that this abnormal proliferation results from a de creased activity of the inducible NOS II and less modulation of this e nzymatic activity by these cells compared to control Wistar Kyoto cell s.