CYTOKINES AND THEIR EFFECTS ON MATURATION, DIFFERENTIATION AND MIGRATION OF DENDRITIC CELLS

Authors
JONULEIT H KNOP J ENK AH
Citation
H. Jonuleit et al., CYTOKINES AND THEIR EFFECTS ON MATURATION, DIFFERENTIATION AND MIGRATION OF DENDRITIC CELLS, Archives of dermatological research, 289(1), 1996, pp. 1-8
Citations number
73
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Archives of dermatological research → ACNP
ISSN journal
03403696
Volume
289
Issue
1
Year of publication
1996
Pages
1 - 8
Database
ISI
SICI code
0340-3696(1996)289:1<1:CATEOM>2.0.ZU;2-F
Abstract
In this review the role of cytokines in the maturation and migration o f phenotypically and functionally diverse dendritic cell (DC) subpopul ations is discussed and their role in the progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is th e most important cytokine for the development of functional DC and act s in concert with a varying mixture of other cytokines such as IL-4, I L-1 and TNF-alpha to direct the development of individual DC subpopula tions.