VINCRISTINE-INDUCED AUTOPHAGY IN MOUSE-LIVER

Authors
KROL T
Citation
T. Krol, VINCRISTINE-INDUCED AUTOPHAGY IN MOUSE-LIVER, Acta Biologica Cracoviensia. Series Zoologia, 38, 1996, pp. 5
Citations number
27
Categorie Soggetti
Zoology
Journal title
Acta Biologica Cracoviensia. Series Zoologia → ACNP
ISSN journal
0001530X
Volume
38
Year of publication
1996
Database
ISI
SICI code
0001-530X(1996)38:<5:VAIM>2.0.ZU;2-P
Abstract
The vincristine effect on the size of autophagy in a mouse liver cell was studied. The activity of cathepsin D, lysosomal esterase, N-acetyl -B-D-glucosaminidase, beta-glucuronidase was determined. In an isolate d lysosomal fraction, it was found that vincristine caused an increase of protein degradation and this action was dependent on dose and time of exposure. It was related to an increase of lysosomal compartment.