Recently, biologists and computer scientists who advocate the ''strong
thesis of artificial life'' have argued that the distinction between
life and nonlife is important and that certain computer software entit
ies could be alive in the same sense as biological entities. These arg
uments have been challenged by Sober (1991). I address some of the que
stions about the rational reconstruction of biology that are suggested
by these arguments: What is the relation between life and the ''signs
of life''? What work (if any) might the concept of ''life'' (over and
above the ''signs of life'') perform in biology? What turns on scient
ific disputes over the utility of this concept? To defend my answers t
o these questions, I compare ''life'' to certain other concepts used i
n science, and I examine historical episodes in which an entity's vita
lity was invoked to explain certain phenomena. I try to understand how
these explanations could be illuminating even though they are not acc
ompanied by any reductive definition of ''life.''