MORPHOLOGICAL-STUDIES OF SKELETAL-MUSCLE IN LACTIC-ACIDOSIS

This paper underscores the contribution of routine morphological exami nation of skeletal muscle in patients with lactic acidosis. Mitochondr ial disorders are by Par the most common causes of primary lactic acid osis, in which muscle biopsy analysis helps in diagnosis and in the se arch for the molecular anomalies, Thus, we focus our attention on one particular point: the contribution of the morphological study of muscl e biopsy in primary lactic acidosis due to mitochondrial disorders, es pecially mitochondrial respiratory-chain diseases.