MDR1 RIBOZYME MEDIATED REVERSAL OF THE MULTIDRUG-RESISTANT PHENOTYPE IN HUMAN LUNG-CELL LINES

Authors
DALY C COYLE S MCBRIDE S ODRISCOLL L DALY N SCANLON K CLYNES M
Citation
C. Daly et al., MDR1 RIBOZYME MEDIATED REVERSAL OF THE MULTIDRUG-RESISTANT PHENOTYPE IN HUMAN LUNG-CELL LINES, Cytotechnology, 19(3), 1996, pp. 199-205
Citations number
26
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Cytotechnology → ACNP
ISSN journal
09209069
Volume
19
Issue
3
Year of publication
1996
Pages
199 - 205
Database
ISI
SICI code
0920-9069(1996)19:3<199:MRMROT>2.0.ZU;2-2
Abstract
An mdr1 hammerhead was introduced into two adriamycin-selected multi-d rug resistant human lung cell lines both of which over-express p-glyco protein. Expression of the ribozyme resulted in a decrease in mdr1 mRN A expression and an increase in drug sensitivity in both cell lines. T his would suggest that the use of specific ribozymes may represent an effective and specific approach in order to restore cellular sensitivi ty towards anti-cancer drugs.