DECREASED IN-VITRO CHEMOSENSITIVITY OF TUMOR-CELLS IN PATIENTS SUFFERING FROM MALIGNANT DISEASES WITH A POOR-PROGNOSIS

The aim of the study was to assess the predictive value of MTT in vitr o assay for evaluation of tumour cell resistance/sensitivity to cytoto xic drugs. We analyzed 105 samples of malignant cells of different ori gin. The study included patients with a diagnosis of acute and chronic lymphatic leukaemia, acute and chronic myeloid leukaemia, non-Hodgkin lymphoma, carcinoma of the lung, stomach and liver, rhabdomyosarcoma and breast carcinoma. The results demonstrate outstanding chemosensiti vity in the majority of childhood acute lymphoblastic leukaemias, medi um chemosensitivity of adult haematopoietic malignant diseases and che moresistance of solid tumour cells. Our preliminary data suggest a goo d correlation between in vitro MTT assay and clinical curability of in dividual malignant diseases.