A NEW ROLE FOR CD23 IN INFLAMMATION

Authors
BONNEFOY JY PLATERZYBERK C LECOANETHENCHOZ S GAUCHAT JF AUBRY JP GRABER P
Citation
Jy. Bonnefoy et al., A NEW ROLE FOR CD23 IN INFLAMMATION, Immunology today, 17(9), 1996, pp. 418-420
Citations number
24
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
17
Issue
9
Year of publication
1996
Pages
418 - 420
Database
ISI
SICI code
0167-5699(1996)17:9<418:ANRFCI>2.0.ZU;2-5
Abstract
CD23, is expressed on a variety of haematopoietic cell types and displ ays pleiotropic activities in vitro. Here Jean-Yves Bonnefoy and colle gues discuss a novel interaction between CD23 and the alpha chains of the beta(2) integrins, CD11b and CD11c, that leads to a proinflammator y pattern of macrophage activation. They describe how neutralizing ant ibodies to CD23 can decrease the severity of murine arthritis.