CURRENT STATUS AND FUTURE PERSPECTIVES OF CYCLOHEXADIENE-CIS-DIOLS INORGANIC-SYNTHESIS - VERSATILE INTERMEDIATES IN THE CONCISE DESIGN OF NATURAL-PRODUCTS

The cyclohexadiene-cis-diols are a group of chiral synthons valuable i n the synthesis of a diverse range of natural products and molecules o f biological interest as well as in the development of concise and ful ly general methodologies for entire groups of organic molecules. Below , the authors briefly summarize the history of these synthons and proj ect future trends in the field, At a time when brevity, enantiocontrol , efficiency and environmental concerns are of prime importance in an ever demanding discipline, the enzymatically produced cis-diols offer the organic chemist one possible method of realizing these goals.