ION-CHANNELS OF CYCLIC TEMPLATE-ASSEMBLED ALAMETHICINS THAT EMULATE THE PORE STRUCTURE PREDICTED BY THE BARREL-STAVE MODEL

Authors
MATSUBARA A ASAMI K AKAGI A NISHINO N
Citation
A. Matsubara et al., ION-CHANNELS OF CYCLIC TEMPLATE-ASSEMBLED ALAMETHICINS THAT EMULATE THE PORE STRUCTURE PREDICTED BY THE BARREL-STAVE MODEL, Chemical communications, (17), 1996, pp. 2069-2070
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
17
Year of publication
1996
Pages
2069 - 2070
Database
ISI
SICI code
1359-7345(1996):17<2069:IOCTAT>2.0.ZU;2-S
Abstract
Single channel measurements of cyclic template-assembled synthetic pep tides (TASP) AL(n)-cyclo2n [AL = Ac-UPUAUAQUVUGLUPVUUG-, U = alpha-ami noisobutyric acid; cyclo2n = cyclo(-Lys-Abz-)(n), Abz = m-aminobenzoic acid] in lipid bilayer membranes reveal that the lowest and the next lowest conductance states of the alamethicin ion-channel are made up o f three and four parallel helices, respectively, as predicted by the b arrel-stave model.